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KMID : 1188320120060030339
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Gut and Liver
2012 Volume.6 No. 3 p.339 ~ p.343
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Effects of the Oral Administration of Mosapride Citrate on Capsule Endoscopy Completion Rate
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Yosuke Ida
Naoki Hosoe
Hiroyuki Imaeda
Rieko Bessho
Riko Ichikawa
Makoto Naganuma
Takanori Kanai
Toshifumi Hibi
Haruhiko Ogata
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Abstract
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Background/Aims:In capsule endoscopy (CE), the capsule does not always reach the cecum within its battery life, which may reduce its diagnostic yield. We evaluated the effect of mosapride citrate, a 5-hydroxytryptamine-4 agonist that increases gastrointestinal motility, on CE completion.
Methods:In a retrospective study, we performed univariate and multivariate analyses for 232 CE procedures performed at our hospital. To identify factors that affect CE completion, the following data were systematically collected: gender, age, gastric transit time (GTT), nonsteroidal anti-inflammatory drug administration, previous abdominal surgery, hospitalization, use of a polyethylene glycol solution, use of mosapride citrate (10 mg), body mass index (BMI), and total recording time.
Results:The univariate analysis showed that oral mosapride citrate, GTT, and BMI were associated with improved CE completion. Multivariate analyses showed that oral mosapride citrate (odds ratio [OR], 1.99; 95% confidence interval [CI], 1.01 to 3.91) and GTT (OR, 2.34; 95% CI, 1.13 to 4.87) were significant factors for improving the CE completion. Oral mosapride citrate significantly shortened the GTT and small bowel transit time (SBTT).
Conclusions:Oral mosapride citrate reduced the GTT and SBTT during CE and improved the CE completion rate.
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KEYWORD
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Capsule endoscopy, Mosapride, Prokinetics
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